Product name: DAT3 thioacetate; 2,3-di-O-acyl trehalose 3 thioacetate
Achievable purity: >90%
Diacyl trehaloses (DAT) are found in the cell envelope of Mycobacterium Tuberculosis. They are a family of three glycolipids with a trehalose core and acyl groups at the 2 and 3 positions. The main difference between the different DAT analogues is the fatty acid at the 3 position. DAT3 features the unsaturated mycolipenic acid on the 3 position and palmitic acid on the 2 position.
DAT3 thioacetate is functionalized with a thioacetate at the terminal position of the palmitoyl ester via a click reaction of DAT3 azide. The thioacetate is air-stable and can be used directly in gold-surface functionalization, or easily deprotected to obtain the free thiol.